![CAS 1268524-70-4|(S)-tèt-butil 2-(4-({4-klowofenil)-2,3,9-triMethyl-6H-thieno[3 ,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate](/uploads/202235855/cas-1268524-70-4-s-tert-butyl-2-4-401403012523.png)
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![CAS 1268524-70-4 | (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate](/uploads/202235855/cas-1268524-70-4-s-tert-butyl-2-4-402130512516.jpg)
![CAS 1268524-70-4 | (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate](/uploads/202235855/cas-1268524-70-4-s-tert-butyl-2-4-402127544224.jpg)
CAS 1268524-70-4|(S)-tèt-butil 2-(4-({4-klowofenil)-2,3,9-triMethyl-6H-thieno[3 ,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Fòmil molekilè: C23H25ClN4O2S
Pwa molekilè: 456.99
Pite: 97 pousan Min.
Pake: 1 g / 5 g / 25 g / 100 g / 1 kg
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Pwodwi Entwodiksyon
Entwodiksyon
(plis)-JQ1 se yon inhibitor BET bromodomain pou BRD4(2) ak IC50 nan 33nM, mare nan tout domèn Bromodomain nan fanmi BET la, men se pa nan domèn Bromodomain lòt pase fanmi BET la.
Spesifikasyon CAS 1268524-70-4|(S)-tèt-butil 2-(4-({4-klowofenil)-2,3,9-triMethyl-6H-thieno[3 ,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
ATIK | SPESIFIKASYON |
InChiKey | DNVXATUJJDPFDM-KRWDZBQOSA-N |
Tanperati depo. | 2-8 degre |
Solibilite | DMSO |
Koulè | blan a bèlj |
Fòm | poud |
Dansite | 1.33 |
Pwen bouyi | 610.4 degre |
pka | 2.05 |
Sentèz deCAS 1268524-70-4|(S)-tèt-butil 2-(4-({4-klowofenil)-2,3,9-triMethyl-6H-thieno[3 ,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Kondisyon
Etap #1: tèr-butil (S)-2-(5-({4-klowofenil)-6, 7-dimethyl-2-oxo{{8 }},3-dihydro{{10}}H-thieno[2,3-e][1,4]diazepin-3-il)acetate Avèk potasyòm tert- butylate Nan tetrahydrofuran nan -78 - 23 degre; pou 0.5h;
Etap #2: Avèk klowofosfat dyetil Nan tetrahydrofuran nan -10 degre; pou 0.75h;
Etap #3: idrazid asid acetic Nan tetrahydrofuran; butan-1-ol nan 23 - 90 degre ; pou 2h;
Baj popilè: cas 1268524-70-4|(s)-tèt-butil 2-(4-({4-klowofenil)-2,3,9-trimetil-6h-thieno[3 ,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, pri, sitasyon, rabè, nan stock, pou vann
