CAS 1346704-33-3|GSK 343

Entwodiksyon
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, 60-fold selective for EZH1 and >1000-pli selektif pou lòt metiltransferaz histon.

Spesifikasyon CAS 1346704-33-3|GSK 343

Sentèz deCAS 1346704-33-3|GSK 343

Kondisyon

Avèk dichloro (1,1'-bis (diphenylphosphanyl) ferocene) paladyòm (II) * CH2Cl2; sodyòm idwojèn nan 1,4-dyoksan; dlo nan 110 degre ; pou 0.333333h; Atmosfè inaktif; Tib sele; iradyasyon mikwo ond;

Referans

Verma, Sharad K.; Tian, ​​Xinrong; Lafrance, Louis V.; Duquenne, Céline; Suarez, Dominic P.; Newlander, Kenneth A.; Romeril, Stuart P.; (...) Creasy, Caretha L.; Miller, William H.

[ACS Medikal Chimi Lèt, 2012, vol. 3, # 12, p. 1091 - 1096]

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