CAS 917389-32-3|LeterMovir
Fòmil molekilè: C29H28F4N4O4
Pwa molekilè: 572.55
EINECS:
Pite: 97 pousan Min.
Pake: 1 g / 5 g / 25 g / 100 g / 1 kg
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Pwodwi Entwodiksyon
Entwodiksyon
Letermovir (AIC246, MK-8228) se yon nouvo konpoze anti-CMV ki vize konplèks anzim tèminal viral la epi li aktif tou kont viris ki rezistan a inibitè ADN polymerase.
Spesifikasyon CAS 917389-32-3|LeterMovir
ATIK | SPESIFIKASYON |
Pwen bouyi | 706.5 degre |
pka | 4.00 |
tanperati depo. | Sele nan sèk, Sere nan frizè, anba -20 degre |
dansite | 1.37 g / cm3 |
Sentèz deCAS 917389-32-3|LeterMovir
Kondisyon:
Etap #1: (S)-methyl 2-(8-fluoro-3-({2-metoksi{-5-(trifluorometil)fenil)-2-({ {8}}(3-metoksifenil)piperazin-1-il)-3,4-dihydroquinazolin-4-il)acetate (2S,3S)-2 ,3-bis(({4-methylbenzoyl)oxy)succinate etil acetate Avèk disodium idrogenfosfat; tert-butil metil etè Nan dlo pou 2h;
Etap #2: Avèk idroksid sodyòm nan dlo a 60 degre; pou 5h; Atmosfè inaktif;
Referans:
Humphrey, Guy R.; Dalby, Stephen M.; Andreani, Teresa; Xiang, Bangping; Luzung, Michael R.; Chante, Zhiguo Jake; Shevlin, Michael; Christensen, Melodie; Belyk, Kevin M.; Tschaen, David M.
[Rechèch ak Devlopman Pwosesis òganik, 2016, vol. 20, # 6, p. 1097 - 1103]
Baj popilè: cas 917389-32-3,917389-32-3,letermovir, pri, sitasyon, rabè, nan stock, pou vann
